I've had a theory for a while...ever since Didi started thinking of the 'open relationship' idea: Didi is not running to Anna, but to GARY! She wants him to be the third member of the relationship; taking them from roommates, to the titular "Menage á Trois" (in both the original, and more recent aspects of the term).
Next comic or two has her running to his work, discovering he is not there, and rather than returning home, she seeks him out through a series of secondary and tertiary characters across the Ma3 and spin-off series SDB & SotR. She tells each person her plans, which has him/her/them think back to how Gary has been a part of their own sexual story (with few exceptions...Jung, for example) and they join the search. Eventually, Didi goes back to the apartment to discover Gary is there with a sexually-supercharged Zii (who is considering jumping Gary more because of her need, but also because she sees how much more open and respectable he has grown since under her tutorage). Didi makes he suggestion that they become a poly trio, and all parties consider and accept. Just as they are starting to engage, the search party arrives, bursting through the door as happens throughout and is a callback to the first comic in the whole series. The story ends. Then in the printed final book, each character gets a "where are they now?" ending for a panel or two. Once again, everyone looks back and sees how their sexual escapades are intertwined with the three main characters, and we harken back to the "Boneularity."
But I've been wrong before.